calumny
Meaning: an attempt to spoil someone else’s reputation by spreading lies
Usage: The local official’s calumny ended up ruining his opponent’s prospect of winning the election.
defamatory
Meaning: harmful toward another’s reputation
Usage: The defamatory gossip spreading about the actor made the public less willing to see the actor’s new movie.
malediction
Meaning: a curse
Usage: The angry villain muttered a malediction as his plan failed.
aspersion
Meaning: a damaging or critical remark; slander
Usage: The rival politicians repeatedly cast aspersions on each others’ integrity.
anathema
Meaning: a cursed, detested person
Usage: Cheating was anathema to the honor committee.